bcr-abl Fusion Proteins

Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.

Also Known As:

Fusion Proteins, bcr-abl; Bcr-Abl Tyrosine Kinase; Oncogene Protein p185(bcr-abl); Oncogene Protein p230(bcr-abl); p185(bcr-abl) Fusion Proteins; p190(bcr-abl) Fusion Proteins; p210(bcr-abl) Fusion Proteins; p230(bcr-abl) Fusion Proteins; Bcr Abl Tyrosine Kinase; Fusion Protein, bcr-abl; Fusion Proteins, bcr abl; Kinase, Bcr-Abl Tyrosine; Protein, bcr-abl Fusion; Tyrosine Kinase, Bcr-Abl; bcr abl Fusion Protein; bcr abl Fusion Proteins; Oncogene Protein p190(bcr-abl); Oncogene Protein p210(bcr-abl); bcr-abl Fusion Protein

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein-Tyrosine Kinases: 7697
        Proto-Oncogene Proteins c-abl: 4
        bcr-abl Fusion Proteins: 781
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Mutant Proteins: 1299
    - Mutant Chimeric Proteins
      - Fusion Oncogene Proteins
        bcr-abl Fusion Proteins: 781
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7697
      - Proto-Oncogene Proteins c-abl: 4
        bcr-abl Fusion Proteins: 781
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        Proto-Oncogene Proteins c-bcr: 8
        bcr-abl Fusion Proteins: 781
      - Fusion Oncogene Proteins
        bcr-abl Fusion Proteins: 781

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